4  RUNX1

• Chromosome 21 deletion can cause FPD

4.1 NIH natural history clinical research study

• Paul Liu at NIH

• Chronic/refractory ITP is a common antecedant history in many of the probands in RUNX1-FPD cohort at NIH

4.2 RUNX1-FPD

• Aspirin-like platelet dysfunction
• MDS/AML (~20-50%)
• Thrombocytopenia (>90%)
• Pregnancy and delivery outcomes in individuals with RUNX1-Familial Platelet Disorder (Deuitch et al. 2025)

Deuitch, Natalie T., Lylach Haizler-Cohen, Amra Kajdic, et al. 2025. “Pregnancy and Delivery Outcomes in Individuals with RUNX1-Familial Platelet Disorder.” British Journal of Haematology, ahead of print, May 29. https://doi.org/10.1111/bjh.20194.