12  Diease Modification in PV

12.1 What is disease modification in PV

It is a biological interference with the malignant program of the disease, sufficient to alter its natural course

12.2 Potential disease modification in PV

12.2.1 Molecular response

• Reduction in JAK2 V617F-VAF

12.2.2 Histological normalization

• Improvement in bone marrow fibrosis and reduced megakaryocytic atypia.

12.2.3 Event Modification

• Delayed transformation to MF or blast phase
• Reduced thrombosis
• Improved survival

12.3 JAK2 Allele burden associations in PV

• Increased WBC
• Venous thrombosis risk
• Presence of splenomegaly
• Risk of progression to MF