6  Novel Therapies in ET

6.1 LSD1 inhibitor

6.2 CTPS1 inhibitor

• Step pharma
• Dencatistat, first-in-class, highly selective, oral CTPS1 inhibitor, into a phase 2 clinical trial for essential thrombocythaemia (ET)
• An Open-Label, Phase 2 Study to Evaluate Safety, Tolerability & Preliminary Activity of the CTPS1 Inhibitor STP938 in Adult Subjects With High Risk Essential Thrombocythaemia Who Are Resistant to or Intolerant of Hydroxycarbamide Therapy